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KMID : 1225720210130060922
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Allergy, Asthma & Immunology Research : AAIR
2021 Volume.13 No. 6 p.922 ~ p.932
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Skin Testing With Peach Peel Extract Versus Serum IgE to Pru p 3 as a Stronger Predictor of Peach-Induced Anaphylaxis
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Somoza Maria Luisa
Pfeifer Ana Prieto-Moreno
Martin-Pedraza Laura
Puche Laura Victorio
Rodriguez Angel Esteban
Blanca-Lopez Natalia
Gonzalez Abel Eva Fernandez
Fernandez-Caldas Enrique
Morales Miriam Moran
Fernandez-Sanchez Francisco Javier
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Abstract
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The most important peach fruit allergen is Pru p 3, followed by Pru p 1, Pru p 4, and Pru p 7. We aimed to assess their role in subjects with peach fruit-induced allergy (anaphylaxis and OAS) and compare skin prick tests (SPT) vs. specific immunoglobulin E (sIgE) for predicting anaphylaxis. We also selected a control group. SPT included prevalent inhalant and plant food allergens plus peach peel extract. The sIgE to Pru p 1, Pru p 3, Pru p 4, and Pru p 7 were quantified. Compared with controls (n = 42), cases (n = 41) were younger (P = 0.003), more frequently female (P < 0.05) and had higher SPT positivity to peach peel (44% vs. 2.4%, P < 0.0001). There were significant differences in sensitization to several pollens: Olea europaea, Artemisia vulgaris, Prunus persica, Platanus acerifolia (all P < 0.001); and fruits: apple (P < 0.04), peanut (P < 0.002), tomato (P < 0.005), and melon (P < 0.05). Pru p 3 sIgE was detected in 61% of all cases (85% anaphylaxis and 38% OAS; P < 0.01 each) and 5% of controls (P < 0.001). Pru p 4 sIgE was present in 19% of cases and 7% of controls. The sIgE to Pru p 1 and Pru p 7 were not found. The odds ratio to predict anaphylaxis for peach peel SPT was 113 (confidence interval [CI], 20?613; P < 0.0001); for sIgE to Pru p 3, 22 (CI, 5.3?93; P < 0.0001); and for SPT positivity to selected plant food allergens, 5 (CI, 1?19; P < 0.05). In our study group, SPT with peel peach extract was a better predictor of anaphylaxis than Pru p 3 sIgE or other variables considered. The role of sIgE to Pru p 1, Pru p 4, and Pru p 7 seemed negligible.
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KEYWORD
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Peach, fruit, pollen, food hypersensitivity, allergy, anaphylaxis, skin tests, immunoglobulin E
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